Abstract

Background: The kadukkai chooranam is a siddha medicine having the potency of strong astringent in nature in terms of taste. It is widely used for the treatment of bleeding disorders especially this drug combination is used for the treatment of dysfunctional uterine bleeding (Menorrhagia). Aim: The aim of this study was to determine the effect of anti-haemorrhagic potency of Kadukkai chooranam in animal models. Methedology: Wistar albino rats of either sex are randomized into four groups of six animals each. Group I received vehicle (1ml/kg; orally), Group II received Kadukkai chooranam drug at the dose of 100mg/kg; orally, Group III received Kadukkai chooranam drug at the dose of 200mg/kg; orally, Group IV served as standard Adrenochrome10µg/kg; orally. The animals were administered the test drug orally and the blood sample were collected periodically for valuation of clotting parameters like prothrombin time, clotting time, bleeding time etc.  Results: The present research work shows that, it enhances the Prothrombin time, Activated Partial Thromboplastin time and Fibrinogen time etc. 200mg/kg of kadukkai chooranam of thrombin time shows 22.21±0.78 when compared the standard 15.82±2.65 which is slightly lows. The action of the kadukkai chooranam is quite higher than the AC of standard drug. Conclusion: Based on the study report, we can conclude that, this drug formulation Kadukkai chooranam has greater potential of preventing haemorrhage related disorders and may be used for clinical management of haemorrhage, where in further clinical investigation/clinical studies are the future need.