IJRPHR is an open access, peer-review journal, devoted to nurture the traditional medicines through reverse pharmacology concepts and implementing it to health care system through health research methods.
show more..
International Journal of Reverse Pharmacology and Health Research (IJRPHR) will give best paper award in every issue.
click Here to download
Evaluation of Anti-histaminic and anti-anaphylactic activity of ancient Traditional Siddha drug Palath ennai
Objective:The objective of this study was to evaluate the invitro anti histaminic and anti anaphylactic potential of traditional drug- Palath Ennai. Materials and methods: We studied scientificallyPalath Ennai for its the active anaphylaxis and mast cell stabilization in rats, and histamine-induced bronchospasm in guinea pigs.Inbred Wistar rats (175–200 g) and guinea pigs (400–600g) of either sex housed in standard conditions (temperature22 ± 2° C, relative humidity 60 ± 5% and 12 h light/dark cycle) were used. They were fed with standard pellet diet andwater ad libitum. Bronchospasm was induced in guinea pigs by exposing them to 1% histamine aerosol under constant pressure (1 kg/cm2) in an aerosol chamber (24 × 14 × 24 cm) made of perplex Glass,of the three groups of six animals each. Results :Mast cell stabilizing potential of Palath Ennai- Antigen challenge resulted in significant degranulation of the mesentric mast cells.Pre treatment of sensitized animals with Palath Ennaiat a dose of 15ml and 30ml/kg, p.o., for 2 weeks resulted in a significant reduction in the number of disrupted mast cells (P <0.001) when challenged with horse serum. conclusion: From the result of the present in-vitro study it was concluded that the test drug Palath Ennaipossess considerable anti-histaminic and anti anaphylactic activity The study is the first step in the scientific validation of Palath Ennaifor anti-histaminic and anti anaphylactic activityin use against allergic and asthmatic conditions.
Siddha ,Anti allergic drug,Palath Ennai, Anti asthmatic drug.