About the Journal
International Journal of Reverse Pharmacology and Health Research (IJRPHR) has mainly focused on reverse pharmacology and applying those into a health research in terms of clinical and public health research. Reverse Pharmacology (RP is the science of integrating bedside documented experiential hits/Clinical expertise into leads by trans-disciplinary exploratory studies (in vitro and in vivo) and to further develop these leads into drug candidates by state-of-the art experimental and clinical research/Public health research. Reverse Pharmacology approaches need to be developed further and optimized as novel means for fast track drug discovery and development of newer, safer and effective drugs.
The Traditional knowledge database allows drug researchers to start from a well-tested and safe botanical material. With AYUSH, the normal drug discovery course of ‘laboratories to clinics’ actually becomes from ‘clinics to laboratories’ – a reverse pharmacology approach. In ayurvedic/Siddha AYUSH medicine research, clinical experiences, observations or available data becomes a starting point. In conventional drug research, it comes at the end. Thus, the drug discovery based on ayurvedic/Siddha AYUSH follows a ‘reverse pharmacology’ path. In the field of drug discovery, classical pharmacology, also known as forward pharmacology, The traditional knowledge-inspired reverse pharmacology described here relates to reversing the routine ‘laboratory-to-clinic’ progress to ‘clinics-to-laboratories’. The novelty of this approach is the combination of living traditional knowledge such as Ayurveda and the application of modern technology and processes to provide better and safer leads.
Lot of scope to Understand the mechanisms of action at multiple levels of biological organization, To optimize safety, efficacy and acceptability of the leads in natural products, based on relevant science. Despite a vast potential and possibilities only a-very few success stories has been reported and documented in Journals and electronic versions so far. Most of the work in this field has remained within clinics of traditional practitioners or confined to academic research laboratories , Improper experiential documentation, Lack of proper identity and implementation of Good Laboratory Practices, Absence of Phase II dose optimizing studies, and Lack of political and financial supports. Through this Journal the awareness regarding the value of their traditional knowledge, to re- activate and re-energize discovery pipeline of Global pharmaceutical industry, phyto-pharmaceuticals to be developed from medicinal plants with evidence of quality, safety and efficacy has to be achieved though progress research.
The scope of RP is to understand the mechanism of action at multiple levels of biological organization and to optimize safety, efficacy and acceptability of the leads from natural products, based on relevant science.
There are three major domains of RP;
(1) the experiential domain covers literature search, Ayurvedic Pharmacoepidemiology and well-defined modest observational therapeutic studies with objective targets of response,
(2) the exploratory animal studies cover indication-relevant in vivo and in vitro studies for efficacy and safety and human pharmacology and phase 2 studies for dose-finding,
(3) the experimental domain involves well-planned experimental and clinical investigation at different levels of biological organization, extended clinical trials and sub-acute safety studies in two animal species.
Reverse pharmacology can be a bridge for translational medicine from the traditional medicine to clinical practice. Such an effort would make healthcare delivery locally relevant and may lead to global discoveries in natural products. But it is essential that we develop multidisciplinary Ra nd D teamwork and infrastructure for reverse pharmacology.
The term "health research," sometimes also called "medical research" or "clinical research," refers to research that is done to learn more about human health. Health research also aims to find better ways to prevent and treat disease. Health research is an important way to help improve the care and treatment of people worldwide.