Abstract

Background In recent years, there has been growing interest in the study of medicinal plants based medicines of Siddha medicines. However, today it is essential to pay for the scientific proof as to whether it is rational to use a plant or any other formulation in any of 32 internal medication forms. Hence the present communication constitutes a pharmacological activities of an Indian medicinal plant, Azima tetracantha based preparation Vembu Karpam.  Objectives The objective is to assess the therapeutic potential of Vembu Karpam for its Anti inflammatory and analgesic activities. Methodology: Anti-inflammatory activity on Vembu karpam was studied using carrageenan-induced paw edema method with dose of   100mg/kg and 200mg/kg in rats. The dose determination studies were carried out according to OECD guidelines and based on our previous acute toxicity study. Hence, 100 & 200 mg/kg was given for the models for analgesic  activity through acetic acid induced writhing reflux in mice. Results: The percentage reduction of paw volume against Carrageenan induced paw oedema was more than the control group and the analgesic activity was also in a significant levels. Conclusions:  Our findings confirmed that the anti-inflammatory, analgesic activities of vembu kudineer could be beneficial for the treatment of Uthra vatha suronitham.