Abstract

Background Jaathipalathichooranam (JPC) is Siddha poly herbal preparation, primarily composed of Myristicafragrans(Linn). In terms of Pharmacological action JPC ishaving significant bronchodilator (Nisha et.al,2017)antispasmodic, antidiabetic and hypolipidemic actions.(Arulmozhi et.al,2007 ). As per the reference text Gunapadamporutpanpunool, the indication of JPC is prescribed primarily for the management of Respiratory disease , DUB and Vatha diseases (Murugesa Mudhaliyar,2016). Objective To determine the acute and sub-acute toxicity effect of the siddha poly herbal formulationJaathipalathiChooranam (JPC). Methods Acute &sub-acute toxicity of JaathipalathiChooranamwasevaluated in wistarrat models with oral administration of JPC 50mg/kgbw for seven days in acute and 20 days in subacute toxicity.All the studies were carried under OECD Guidelines. Results TheJaathipalathiChooranam has not produced any acute and sub-acute toxicity symptoms, no changes in corporal weight and haematological parameters and hepatic enzymes like SGOT & SGPT . The result of the study suggests that JPC is safe to use for long term prescription. Conclusion The results suggested that Jaathipalathichooranamis found to benon-toxic, when action of JPC was analyzed onhematopoietic and leucopoietic systems.