Abstract

Background: The root decoction of Nannari ver, Hemidesmus indicus (Linn) from Asclepiadaceae family has been using in traditional medicine for a long period. In Tamilnadu and even in Kerala people are  more using   Hemidesmus indicus, (Linn) Commonly in siddha this medicine  used as diuretic and to reduce body heat. Objective: To evaluate the acute and sub-acute toxicity of Nannari ver Ooral kudineer(NVK) on experimental in  Wister albino rat models. Materials and Methods: Acute toxicity  study was carried out in  Male and female Wister albino rat . Administration of a single dose of 4000mg/kg of Nannari ver Ooral kudineer by gavages to five rat were found no mortality. In 1/20th dose was used as the highest therapeutic dose. In sub acute toxicity analysis Wister rats has received daily 50 to 200mg/kg /bwt for 28 days.       Results: No significant changes in  WBC, RBC were observed between control and test groups following repeated administration of Nannari ver Ooral kudineer. The animals treated with NVK showed normal growth pattern and body weight compared with control rats . There was a slight decrease in plasma glucose level and increased in Hb levels,after administration of NVK (400 mg.kg-1). Conclusion: At the end of study  there was no an undesirable effect of  all organs and   safe for consumption by human health.