A Case Report on the Siddha Management Of Non Healing

Necrotising Diabetic Foot Ulcer

Dr.M.K. Sangeetha, Siddha consultant, Dr. Rajkumars siddha clinic, chennai-47.

Dr. K.Rajakumar, Siddha consultant, Dr. Rajkumars siddha clinic, Chennai -47.,

Dr. S. Karthik Nagarajan, Emergency medical officer, National institute of Siddha., chennai-47.,

ABSTRACT

Background: Non healing necrotising Diabetic foot ulcer (DFU) is quoted as Madumegapun (Diabetic Ulcer) in the Siddha literatures. Diabetic foot is one of the most significant and devastating complications of diabetes and is defined as a foot affected by ulceration that is associated with neuropathy.

Case Report: Fifty two years old female was visited in Dr. Rajkumars siddha clinic., Chennai-47. with complaints of ulcer in the left plantar aspect of foot with foul odour, pus discharge from the ulcer, swelling in the peri-wound area since one month.

Case Assessment: Severity of the ulcer was measured by the Diabetic Ulcer Severity Score (DUSS), and prognosis. And, it emphasizes on the importance of proper medication for DFU and to focus on the Siddha management withAavarai kudineer Chooranam (Anti-diabetic Siddha drug) andMaththan Thailam (Wound healing Siddha external Oil) along withTriphala decoction wash and Parangipattai chooranam tablet and Rasagandhi mezhugu capsule internally.

Conclusion: Intervention of Siddha medicine can potentially heal the Diabetic foot ulcer with regulating the blood sugar level. They could have a massive impact, in reducing necrotised tissues and depth of the wound and it covers the wound with granulation tissues as well as it reduces overall infection rates, amputations, plastic surgeries and improving the overall quality of life and lower the economic burden in treating DFU and this procedure is also a cost effective , easily undergoing and with high safety margin.

Keywords: Siddha System of Medicine, Diabetic Foot Ulcer (DFU ), Madhumegapun, Maththan thailam

INTRODUCTION

According to the World Health Organization's 'The World Health Statistics 2020' report, India has the largest number of diabetics in the world and is now being called the "Diabetic Capital of the World"1. It is estimated that there are 40 million people with diabetes in India currently and by 2025 this number will swell to 70 million.[1]

A study that assessed 3,619 events of all-cause mortality found that there were an additional 58 deaths per 1,000 each year of patients with diabetic foot ulcer. Peak prevalence is between 60 and 80 years. Approximately 15 % of persons with diabetes will develop foot ulceration during their lifetime 4. 5–24 % of them will finally lead to limb amputation within a period of 6–18 months after the first evaluation.[2]

Diabetic foot is one of the most significant and devastating complications of diabetes and is defined as a foot affected by ulceration that is associated with neuropathy and/or peripheral arterial disease of the lower limb in a patient with diabetes.[3] The development of neurotrophic foot ulcers in patients with diabetes mellitus has several components, including neuropathy, biomechanical pressure and vascular supply disorders. Peripheral neuropathy is clearly the dominant factor in the pathogenesis of diabetic foot ulcers.[4]

The Siddha system is the most ancient medical system practiced by the Dravidians. Many herbals and herbo-mineral Siddha drugs have been used for the management of Diabetes[5] as well as Diabetic ulcers. Diabetic ulcer is correlated to Madumegapun or ‘Valicilaip pun’ in Siddha system of medicine[6]. According to the Siddha fundamental theory, wounds are classified into 16 types; these types are comprised in the 3 major divisions that areVali Viranam, Azhal Viranam and Iya Viranam. Vali and Azhal category of wound are treated with oil based (Thailam) medicines and Iya category of wounds[7] are treated with oil (Thailam) or powder-based (Chooranam/Parpam) medicines. Wound care management in Siddha system is unique, because of its 32 type of external therapeutic care.

Ulcers are also treated by various external therapies like Kattu (Bandage), Poochu (Liquide application), Podi (Powder),Kalimbu (Ointment), Kaaram (Chemical cautery), Seelai (Medicated gauze), which is mentioned in the Siddha system. According to this theory, treating medicines are neutralize the Iyam.

This case report validates the Siddha medicine’s contribution to the successful management and healing of a compound foot lesion. Here, we report the case of Madhumega Pun or Valicilaipun (chronic non-healing diabetic foot ulcer) in the left plantar, which was treated with topical application of Siddha medicine. Case patient was treated by internally Aavarai kudineer Chooranam Parangipatttai chooranam tablet and Rasagandhi mezhugu (Anti-Diabetic Siddha drugs), externally by Maththan thailam (Wound healing Siddha external oil) and Triphala decoction wash externally .

Patient information:

Fifty two years old female was visited Dr. Rajkumars siddha clinic.,

Chennai-47 with complaints of ulcer in the left plantar aspect of foot with foul odour, pus discharge from the ulcer, swelling in the peri-wound area since one month

Present Medical History:

Patient was visited with complaints of non healing ulcer in the left plantar aspect of foot with foul odour, pus discharge from the ulcer, swelling in the peri-wound area since one month.

Past Medical History:

Patient had Diabetes mellitus for the past 10 years under allopathic treatment and has no history of Systemic hypertension, Dyslipidemia ,Bronchial asthma and Jaundice.

Siddha Interpretation of the Patients condition:

Pathophysiology:

In case of Madumegam all the three vital humors were affected followed by them the seven udal thathus also gets affected. In case of Madhumega pun or Valicilai pun there will be foul discharge from the ulcer, pain will be presenting in the peri wound region and th discharge will be blackish-brown in colour and it will present as chronic ulcer because of the affected three humors if untreated it will lead to gangrene .

Therapeutic intervention:

Therapeutic intervention consisted of three components namely medicines ,diet and regimen. Here it is pertinent to point out that the three medicines used in the study are all classical preparations namely Aavarai kudineer chooranam, Parangipattai chooranam tablet and Rasagandhi mezhugu capsule as internally and Maththan thailam and triphala powder wash as externally .

Table no:1 Therapeutic intervention

Drug

Dose

Mode of usage

Time of usage

1.Aavarai kudineer chooranam

2.Parangipattai chooranam tablet

3.Rasagandhi mezhugu capsule

4.Maththan thailam

5.Triphala powder wash

60ml of decoction

2 tablets

1 capsule

Internally

Internally

Internally

Externally

Externally

Twice a day before food

Twice a day before food

Twice a day before food

Twice a day

Twice a day

Outcome – measured outcome:

During first day of treatment patient was given with both internal as well as external medicines namely Aavarai kudineer chooranam, Parangi pattai chooranam and Rasagandhi mezhugu as internally and Maththan thailam and Triphala powder wash as externally which was adviced to follow regularly. Outcome was measured on the basis of two assessment scales namely Wound was analyzed in the following three ways. Severity of the ulcer was measured by the DUSS (Diabetic Ulcer Severity Score).

This case report validates the Siddha medicine’s contribution to the successful management and healing of a compound foot lesion.

Table no : 2 DIABETIC ULCER SCORING SYSTEM :

VARIABLES

SCORE 0

SCORE 1

Palpable pedal pulses

Presence

Absence

Probing to bone

No

Yes

Ulcer site

Toes

Foot

Ulcer number

Single

Multiple

.

Before treatment score of the patient with respective of DUSS was 4 and after treatment it was reduced to 0.

Table no : 3 Treatment and observations:

DAYS

OBSERVATIONS

TREATMENT

1st day 15-07-2020

Ulcer was with present with foul odour ,discharge along with necrotized cellular debris.

Patients history were taken and then Wound was cleaned and dressed with Maththan Thailam and Triphala wash regularly

2nd day 16-07-2020

Necrotized tissues started disappearing.

Urine and Blood sample were collected for investigation

3rd day 17-07-2020

Pus discharge was reduced .The colour of edges of the ulcer started becoming redness and got reduced in circumference.

Aavarai kudineer Chooranam-2gm thrice daily and Parangipattai Chooranam tablet -2 and Rasagandhi mezhugu capsule-1 was twice Daily were prescribed orally

10th day 25-07-2020

Foul odor, pus discharge in the wound was completely stopped. Swelling in the Peri-wound area was

reduced

Internal and external medicines were taken regularly.

20th day 05-08-2020

Pain around the wound area. Bony abrasives were expelled from the wound at the time of dressing

Internal and external medicines were taken regularly.

30th day 15-08-2020

Depth of the wound was closed. Necrotic tissues were completely disappeared, and granulation tissues

were covered the wound area

Internal and external medicines were taken regularly.

40th day 25-08-2020

Blood and Urine samples were collected investigations.

Internal and external medicines were taken regularly.

50th day 05-09-2020

Wound was completely closed by the epithelial cells

Internal medicines were taken regularly.

COMPARATIVE HAEMOTOLOGICAL PARAMETERS:

Table no :4

Haematological parameters

Before treatment

After treatment

Total count(cells/cu.mm)

8000

8600

Neutrophils

70

75

Lymphocytes

20

28

Basophils

0

0

Eosinophils

10

8

Monocytes

0

0

Hemoglobin

9.0

12

ESR(Mm/Hr)

100

40

COMPARATIVE BIOCHEMICAL PARAMETERS:

Table no: 5

Biochemical parameters

Before treatment

After treatment

FBS

160

120

PPBS

300

190

HBA1C

7.5

7.3

SERUM CHOLESTROL

100

100

HDL

29

30

LDL

50

60

BLOOD UREA

30

30

SERUM CREATININE

1.0

1.0

TRIGLYCERIDE

100

90

Before treatment

After treatment

Patient perspective:

During the course of the treatment the patient feels good and comfort on doing his daily routine as well as his quality of life and self esteem was improved. Patient was really satisfied with the treatment and she was willing to follow the treatment .

Discussion:

Fifty two years old female patient from Tamilnadu was visited in the clinic for the complaints of non healing ulcer in the left plantar aspect of big toe ,foul odor, pus discharge from the ulcer. She was referred for the amputation of the foot by the doctors but with the Siddha therapeutic procedures were helped to relieve from the amputation and improve QOL of the patient.

Treatment was initiated with Internally Aavarai kudineer chooranam was given as well as Parangipattai chooranam tablet and Rasagandhi mezhugu was also twice a day before food given. Externally, application of Maththan thylam and Triphala powder wash was advised and followed regularly.

The ingredients used in Maththan thylam has wound properties, skin generation, angiogenesis and bacterial inhibition . Aavarai kudineer chooranam has the property of decreasing blood glucose level and Triphala powder has the function of wound healing, anti-bacterial as well as skin generation. Results were tabulated and it shows a significant reduction in blood sugar level ,as well as rise in level of neutrophils and lymphocytes. The study has satisfactory improvement in the non healing chronic diabetic ulcers based on the assessment tools of DUSS which compared before and after treatment.

Conclusion:

Diabetic ulcer is one of the major complications of Diabetes mellitus and on critical stage it leads to amputation in many occasions so the above study clearly indicates that not only Diabetic ulcer cured but also Fasting blood glucose, HBA1C as well as reduced and also there is progressive increase in neutrophils and lymphocytes also. India is a country of trying to provide the medical need of the people with cost effective as well as improving quality of people by means of traditional system of medicine.

Declaration of Patient consent

The authors certify that they have obtained all appropriate written informed consent from the patients for the publication of this case report and accompanying images

REFERENCES

1. Alexiadou K, Doupis J. Management of Diabetic Foot Ulcers. Diabetes Ther [Internet] 2012 [cited 2021 Feb 21];3(1). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508111/

2. Neelambika GB, Balu V, Rashel Rego M, Kesari C. Integrative approach for diabetic foot management– a case report. J Ayurveda Integr Med [Internet] 2018 [cited 2021 Feb 21];9(4):298–301. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314231/

3. Younes NA, Albsoul AM, Awad H. Diabetic heel ulcers: a major risk factor for lower extremity amputation. Ostomy Wound Manage 2004;50(6):50–60.

4. Kruse I, Edelman S. Evaluation and Treatment of Diabetic Foot Ulcers. Clin Diabetes [Internet] 2006 [cited 2021 Feb 21];24(2):91–3. Available from: https://clinical.diabetesjournals.org/content/24/2/91

5. Agbi KE, Carvalho M, Phan H, Tuma C. Case Report: Diabetic Foot Ulcer Infection Treated with Topical Compounded Medications. Int J Pharm Compd 2017;21(1):22–7.

6. K. N. Kuppusamy Muthaliar. Siddhar Pothu Maruthuvam. 2nd ed. Chennai: Department of Indian Medicine and Homeopathy; 2012.

7. Thiyagarajan R. Siddha Sirappu Maruthuvam (Special Medicine-Siddha). 4th ed. Chennai: Department of Indian Medicine and Homeopathy; 2017.