Abstract

Varma maruthuvam is a unique system of medicine which comes under in siddha system. Kaalkavali varma kudineer is one of the internal medicine mentioned in the textbook of varma marunthu seimuraigal (Formulary of varma medicine) which indicates kaal vali, veekam, ullankal narambu virviruppu, kaalkavali varma noigal. Osteo arthritis of knee is a form of arthritis that features the breakdown and eventual loss of the cartilage of knee joints. The most common symptoms of Osteo arthritis, pain in the joint after repetitive use along with loss of range of motion and function. In varma text, perumootu vatham occurs due to derangement of azhal or pitha dhosam which is basic reason of this disease. The deranged pitham heat dries up the synovial fluid present in the knee joint resulting in crepitation, restricted movements and later swelling. In textbook of Vadha Noi Nidhanam-800(649/800) Signs and symptoms of perumootu vatham can be correlated with osteo arthritis of knee joint.  The aim  of  the  study  was to evaluate the Biochemical analysis of  the  trial  drug Kaalkavali varma kudineer and it indicates   the  presence  of   calcium, Sulphate, chloride, starch, ferrous  iron,  unsaturation compound, Reducing sugar, aminoacid which revealed the enhancement   of  therapeutic action in vadha diseases.