Abstract

Epilepsy is one the common neurological disorder worldwide, epileptic seizures syndrome can be due to wide variety of causes including genetic, developmental or acquired ones. Epileptic seizures are seizure events that occur due to excessive abnormally synchronized, localized or widely distributed neuronal electrical discharges. With about 80 percent of cases thought to be in developing countries where it is linked to superstition. Anti-epileptic drugs (AEDs) are adverse side effects. Herbal medicine has always been traditionally part of treatment for epilepsy. Herbal medicines are generally well tolerated with fewer side effects. WHO in partnership with internal bureau for epilepsy (IBE), International league against epilepsy (ILASE) suggested that around 1% of world population at any time (about 50million people worldwide) is affected with this neurological disorders. The annual incidence ranges from 20 to 70 cases per 100,000 and the point prevalence is 0.4 to 0.8 percent. The incidence rates are highest in childhood, febrile convulsants which occur in an approximately 5 percent of childhood. Method: Swiss albino rats of both sexes were used for this study. Animals were divided in five groups, each containing ten mice. Experimental procedures and protocols for the study were approved by Kalasalingam Academy of Research and Education, Virudunagar, Tamil Nadu. Maximal electro shock (MES) were used for the evaluation of the anticonvulsant activity of Yogaraja Guggulu.  Conclusion: Potential herbal remedies have shown positive results in animal models. It remaining unclear many make it into clinical trials and eventually making part of the AED list. More rigorous research applying strict research methodology with uniform herbal combinations, polyherbal compound medicines, as well as clinical studies are urgently.